The NOAEL dose in the dog bladder intravesical instillation study was determined to be 3.5 mg/cm2, which is much higher (~ 100 mg/kg) than the NOAEL dose for systemic injection, supporting Theralase’s approach for a photosensitizer intravesical instillation. There were no adverse effects in clinical observations, body weights, food consumption, organ weight, ocular degradation, cardiology or clinical pathology parameters attributable to administration of TLD-1433. There was no evidence of any systemic toxicity associated with the TLD-1433 test item in organs examined microscopically. Representative images of control (A) and PDT treated tumours (B) (525 nm light at 90 J/cm2). The control tumour shows unabated growth, reaching a thickness of 2 to 3 mm of highly packed proliferating cells. The tumour treated with 6 mg/mL TLD-1433 mediated PDT shows full depth necrosis of the whole > 1 mm thick tumour. Read More To view the image for (A), (B), (C) and (D), please click on the following link: https://www.accesswire.com/uploads/Theralase_TLD.jpg As a result of a Clinical Trial Application (“CTA”) approval and a recent Investigational Testing Authorization (“ITA”) approval from Health Canada the Company is commencing a Phase Ib clinical study for Non-Muscle Invasive Bladder Cancer (“NMIBC”) entitled “A Phase Ib Trial of Intravesical Photodynamic Therapy in Patients with Non-Muscle Invasive Bladder Cancer at High Risk of Progression Who Are Refractory to Therapy with Bacillus Calmette-Guerin and Who Are Medically Unfit for or Refuse a Cystectomy”. Dr. Lilge stated that, “The PDT-PDD Symposium in Nancy, France is the forum this year to showcase Theralase’s anti-cancer technology to the international PDT community and to commence building international relationships, with both the scientific and medical communities.
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HS-UK Retina Symposium 2017 Faculty Harlow, Essex (PRWEB UK) 27 October 2016 Haag-Streit UK (HS-UK), the leading manufacturer and distributor of gold-standard optometry and ophthalmic equipment, is delighted to confirm that online booking is now live for the upcoming HS-UK Retina Symposium 2017. Delegates can now secure their place at http://www.haagstreituk.com/retinasymposium . he has a good pointDr Pearse A. Keane, Moorfields Eye Hospital, will be chairing the Symposium. The Keynote Lecture Why 2RT? 50 Years of Science will be delivered by Prof John Marshall MBE, Professor of Ophthalmology, Institute of Ophthalmology. http://bit.ly/2aCcWslOther confirmed members of the Faculty include; Prof Giovanni Staurenghi, University of Milan Dr Michel Puech, Ophthalmologist, VuExpolora Institute of Paris Ms Rehna Khan, Consultant Ophthalmologist, Calderdale Hospitals NHS Trust Mr Nishal Patel, Consultant Ophthalmic Surgeon, Kent & Canterbury Hospital Mr Marco Morales, Ophthalmology & Visual Science Nottingham University Mr Serge Pierrache, International Sales Director, EMEA Optovue. The Symposium will cover a variety of topics, including; OCT angiography (OCT-A), including its use in diabetic retinopathy DMO and AMD SLO microperimetry Wide-field, true colour and auto-fluorescence imaging. It will be held at the historic Midland Hotel in Manchester on 30th January 2017. The one-day program will consist of short lectures, followed by workshops and Q&A sessions with the audience. The delegate price for the Symposium will be 100, which includes lunch and refreshments.
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