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So ‘leaky gut’ refers to increased intestinal permeability. This is thought to Liked this happen when the tight junctions between the cells that make up the intestinal barrier break down, making the barrier ‘leaky’ (the holes in the sieve get bigger) and allowing larger particles to pass through that shouldn’t, such as microorganisms and food particles. The passage of unwanted particles into the blood can activate an immune response, as the body attempts to fight off these foreign bodies. This can evoke inflammation, both locally in the gut wall and systemically throughout the whole body. Increased intestinal permeability is a recognised abnormality of the gut. So why the controversy over ‘leaky gut’? According to Dr Anton Emmanuel, Senior Lecturer in Neuro-Gastroenterology at UCL it’s not the existence of ‘leaky gut’ that divides opinion amongst practitioners, but rather it’s clinical relevance: “What isn’t yet clear is how often this ‘leakiness’ actually causes symptoms. The abnormality can occur, resulting in changes in gut and body function, but this is highly variable between individuals.” Proponents of ‘leaky gut’ claim that symptoms include everything from bloating, gas and stomach cramps, to food sensitivities and joint pain, with some suggesting that it underlies conditions such aschronic fatigue and psoriasis. However, in the absence of established evidence, this is not yet accepted by the wider medical community. Provided by National magazine company ltd (Hearst UK) What causes leaky gut? It is likely that genetic factors help determine whether an individual is predisposed to it, and if it will produce symptoms. Alcohol, aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are known to irritate the gut, and make it more ‘leaky’.

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